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Impact of shampooing or water immersion on the effectiveness of Effipro ® Duo against the further development of flea eggs: A randomised, blinded, controlled study in dogs

The study objective was to identify any impact of water immersion or shampooning on the efficacy of a fipronil-pyriproxifen spot-on formulation (Effipro (R) duo, Virbac, Carros, France) against further development of flea eggs collected from dogs experimentally infested with gravid fleas (Ctenocephalides felis). Thirty healthy dogs were randomly allocated to one of five groups: group 1 (negative control), group 2 (shampooed 2 h prior treatment), group 3 (shampooed 30 and 58 days post-treatment), group 4 (water-immersed 30 and 58 days post-treatment), and group 5 (positive control). On day 0, dogs in groups 2, 3, 4 and 5 were treated with Effipro (R) Duo (0.67 ml per dog >= 2 to 10 kg and 1.34 ml per dog >= 10 to 20 kg). Dogs were infested with at least 50 gravid fleas on days 1, 28, 56, 70, and 84. Flea eggs were collected for two consecutive nights following flea infestations and incubated for approximately 35 days to allow adult flea emergence. No statistically significant differences (P>0.05) in adult flea emergence were recorded between any of the treated groups. A full efficacy (100%) was recorded up to day 30 in the four treated groups.The efficacy remained high up to 3 months post-treatment for dogs shampooed or water immersed (>=91%, except day 57 in group 3) and very high for the treated group with no shampooing or water immersion (>= 97%, except day 57 und 85). Both water emmersion and shampooing had no significant impact on the efficacy of Effipro (R) Duo against further development of flea eggs in dogs.

DATE » 31.05.2016

AUTHORS » K. de Mari, C. de Vos, K. Hellmann, C. Navarro, S. Bonneau

PUBLISHED » Veterinary Dermatology, Volume 27, Supplement 1, P114: "8th World Congress on Veterinary Dermatology", May 31-June 4th, 2016, Bordeaux, France; Wiley Blackwell.